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-These products are for laboratory use-
What is 5-Amino-1MQ...?
A quinolinium-based, selective NNMT inhibitor used to interrogate NNMT biology in cells and animal models of obesity, insulin resistance, and related metabolic phenotypes
How does 5-Amino-1MQ work?
It inhibits NNMT, lowering 1-MNA formation while increasing availability of nicotinamide for NAD⁺ salvage and SAM for other methylation reactions; adipocytes show increased NAD⁺ and altered lipid handling in models.
5-Amino-1MQ has potential to:
Reverses diet-induced obesity phenotypes in mice and reduces white adipose tissue while preserving lean mass.
Increases cellular NAD⁺ and SAM availability and lowers intracellular 1-MNA, consistent with enhanced NAD⁺ salvage and a favorable “methyl economy”.
Augments adipocyte energy expenditure and remodels lipid metabolism, with links to polyamine flux and epigenetic marks observed with NNMT knockdown.
Combines with dietary improvement to accelerate weight/fat loss and improve composition versus diet alone.
NNMT dysregulation is implicated across obesity, insulin resistance, liver pathology, and other disorders; selective NNMT inhibitors such as 5-Amino-1MQ are prominent tool compounds for target validation
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