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What it is
Tadalafil is a lab-made small molecule. It blocks an enzyme called phosphodiesterase type 5, or PDE5, which normally breaks down a cell signaling molecule called cyclic GMP.
Why researchers study it
Researchers study PDE5 blockers in animal models to learn how cyclic GMP signaling affects blood vessels and tissue blood flow. Tadalafil is a common test compound for that work because its action in test systems lasts longer than that of related compounds.
Study spotlight
In male rats with a temporarily blocked coronary artery, researchers measured the area of damaged heart tissue, blood pressure, and heart rate. The paper reported a smaller damaged area in tadalafil-treated rats than in vehicle-treated controls, at 42 percent versus 54 percent, with comparable heart rates.
Read the study: https://pubmed.ncbi.nlm.nih.gov/16858368/
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor compound.
Supplied at 20mg in a pack of 5. Brand may vary depending on stock.
Store in a cool, dry place away from direct light.
For Laboratory use only.
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